The ultrastructure of ethionine-induced hyperplastic liver nodules was compared to the adjacent nonnodular liver in the same rat and also to hyperplastic liver nodules induced by 2-fluorenylacetamide. Several reproducible cytostructural
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چکیده
The ultrastructure of ethionine-induced hyperplastic liver nodules was compared to the adjacent nonnodular liver in the same rat and also to hyperplastic liver nodules induced by 2-fluorenylacetamide. Several reproducible cytostructural alterations were noted in ethionine-induced hyperplastic liver nodules of fasted animals but not in adjacent nonnodular liver. This set of alterations was quite similar to those noted in the hyperplastic liver nodules induced by 2-fluorenylacetamide. These observations suggest the hyperplastic liver nodules induced by different carcinogens have similar characteristics and represent a new cell population distinct and intermediate between adjacent nonnodular liver and hepatocellular carcinoma.
منابع مشابه
Membranes during dl-Ethionine Hepatocarcinogenesis Functional and Structural Alterations of Liver Ergastoplasmic
SUMMARY Different functional and structural properties of rat liver microsomes were studied during hepatocarcinogenesis induced by 0.25% m-ethionine. During the first to fourth months of ethionine feeding, great decreases of cytochrome P-450 content, reduced nicotinamide adenine dinucleotide phosphate-dependent lipid peroxidation, and aminopyrine demethylase activity occurred. No changes in the...
متن کاملFunctional and structural alterations of liver ergastoplasmic membranes during DL-ethionine hepatocarcinogenesis.
Different functional and structural properties of rat liver microsomes were studied during hepatocarcinogenesis induced by 0.25% DL-ethionine. During the first to fourth months of ethionine feeding, great decreases of cytochrome P-450 content, reduced nicotinamide adenine dinucleotide phosphate-dependent lipid peroxidation, and animopyrine demethylase activity occurred. No changes in the reduce...
متن کاملCellular analysis of liver carcinogenesis: the induction of large hyperplastic nodules in the liver with 2-fluorenylacetamide or ethionine and some aspects of their morphology and glycogen metabolism.
A dietary regimen is described whereby large hyperplastic nodules can be obtained in over half the rats fed either of the two hepatocarcinogens, ethionine or 2-fluorenylacetamide. The nodules are composed predominantly of hepatocytes which show morphologic and biochemical differences from the surrounding nonhyperplastic liver. The glycogen or its metabolic control are different in the nodule in...
متن کاملCellular Analysis of Liver Carcinogenesis: the Induction of Large Hyperplastic Nodules in the Liver with 2-Fluorenylacetamide or Ethionine and Some Aspects of Their Morphology and Glycogen Metabolism1
A dietary regimen is described whereby large hyperplastic nodules can be obtained in over half the rats fed either of the two hepatocarcinogens, ethionine or 2-fluorenylacetamide. The nodules are composed predominantly of hepatocytes which show morphologic and biochemical differences from the surrounding nonhyperplastic liver. The glycogen or its metabolic control are different in the nodule in...
متن کاملNormal rat liver hepatocytes and the hepatocytes of hepatic nodules induced by N-2-fluorenylacetamide respond to 70% hepatectomy with vigorous mitotic activity. The administration of L-asparaginase at the time of operation
Normal rat liver hepatocytes and the hepatocytes of hepatic nodules induced by N-2-fluorenylacetamide respond to 70% hepatectomy with vigorous mitotic activity. The administration of L-asparaginase at the time of operation delays the mitotic cycle of every normal hepatocyte by 10 to 12 hr. When L-asparaginase was administered to rats which had received N-2-fluorenylacetamide, an 80% inhibition ...
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تاریخ انتشار 2006